AB155. High-throughput sequencing of small RNA component of penile in a post-radical prostatectomy model of erectile dysfunction

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau castrated rats than in controls, and testosterone restored these decreases (each P<0.05). The expression levels of cyclooxygenase-2 (COX-2), prostacyclin synthase (PTGIS or PGIS), endothelial nitric oxide synthase (eNOS) and phospho-eNOS were reduced in castrated rats compared with controls. The expression levels were significantly elevated in rats treated with testosterone (each P<0.05). The expression levels of p40phox and p67phox were increased in castrated rats, and testosterone significantly reduced these increases (each P<0.05). ROS production was markedly enhanced in castrated rats, and testosterone administration reversed this effect (P<0.05). Conclusions: Testosterone can ameliorate ED after castration by reducing ROS production and increasing activity of the eNOS/cGMP and COX-2/PTGIS/cAMP signaling pathways.